3-(2-Bromo-acetyl)-benzoic acid methyl ester synthesis
- Product Name:3-(2-Bromo-acetyl)-benzoic acid methyl ester
- CAS Number:27475-19-0
- Molecular formula:C10H9BrO3
- Molecular Weight:257.08
62423-73-8
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18107-18-1
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27475-19-0
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Yield: 66%
Reaction Conditions:
in methanol;toluene at 20; for 0.0833333 h;
Steps:
40.1
Step 1: methyl 3-(bromoacetyl)benzoate; A solution of 3-(bromoacetyl)benzoic acid (from Fluorochem) in toluene/MeOH (7:3) was treated with trimethylsilyl diazomethane (2 M solution in Et2O, 1 eq.). After stirring at RT for 5 min, the reaction mixture was concentrated to afford (66%) the title compound as a solid. 1R NMR (300 MHz, DMSO-de, 300K) δ 3.89 (s, 3H), 5.00 (s, 2H), 7.67-7.76 (m, IH), 8.18-8.28(m, 2H), 8.49 (s, IH). MS (ES+) Ci0H9BrO3 requires: 256, found: 257 (M+H)+.
References:
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA WO2007/144669, 2007, A1 Location in patent:Page/Page column 46
21860-07-1
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27475-19-0
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$45.00/100mg
586-42-5
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$10.00/1g
27475-19-0
71 suppliers
$45.00/100mg