Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 2-(3-Chloro-phenyl)-pyrrolidine
298690-74-1

2-(3-Chloro-phenyl)-pyrrolidine synthesis

3synthesis methods
To a solution of substituted benzoic acid inabsolute ethyl alcohol was slowly added thionyl chloride. The mixture was heated to reflux for 2h, and then cooledto room temperature. The solvent was removed and the solid residuewas dissolved in ethyl acetate, and washed withsaturated NaHCO3 solution. After a series of reactions, 3-(2-chloro-phenyl)-pyrrolidine can be obtained.
3-Chlorobenzoic acid

535-80-8
435 suppliers
$5.00/5g

2-(3-Chloro-phenyl)-pyrrolidine

298690-74-1
85 suppliers
$45.00/100mg

-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: thionyl chloride / 2 h / Reflux
2: sodium hydride / tetrahydrofuran / 3 h / Heating
3: hydrogenchloride / tetrahydrofuran; water / Reflux
4: acetic acid; sodium tetrahydroborate / methanol / 20 °C / Cooling with ice

References:

Wang, Junwei;Song, Qiao;Xu, Anhua;Bao, Yu;Xu, Yungen;Zhu, Qihua [European Journal of Medicinal Chemistry,2017,vol. 130,p. 15 - 25]

ETHYL 3-CHLOROBENZOATE

1128-76-3
125 suppliers
$8.00/1g

2-(3-Chloro-phenyl)-pyrrolidine

298690-74-1
85 suppliers
$45.00/100mg

References
88-12-0 Synthesis
N-Vinyl-2-pyrrolidone

88-12-0
480 suppliers
$6.00/25g

ETHYL 3-CHLOROBENZOATE

1128-76-3
125 suppliers
$8.00/1g

2-(3-Chloro-phenyl)-pyrrolidine

298690-74-1
85 suppliers
$45.00/100mg

References

2-(3-Chloro-phenyl)-pyrrolidine Related Search:

2-(4-Chlorophenyl)pyrrolidine (R)-2-(2-Chlorophenyl)pyrrolidine