3-(2-HYDROXYETHYL)-1,3-BENZOTHIAZOL-2(3H)-ONE synthesis
- Product Name:3-(2-HYDROXYETHYL)-1,3-BENZOTHIAZOL-2(3H)-ONE
- CAS Number:21344-50-3
- Molecular formula:C9H9NO2S
- Molecular Weight:195.24
Yield:21344-50-3 98%
Reaction Conditions:
with potassium hydroxide in water;
Steps:
2 EXAMPLE 2
EXAMPLE 2 To a stirred solution containing 151.2 g (1.0 mol) of 2-hydroxybenzothiazole, 66 g (1.0 mol) of 85% potassium hydroxide and 300 ml of water, 88.6 g (1.1 mol) of 2-chloroethanol was added in one portion. The stirred reaction mixture was heated at 90°-100° C. for 5 hours and at 25°-30° C. for 18 hours. After cooling to 10° C., the reaction mixture was stirred at 0°-10° C. for 30 minutes. The product, 3-(2-hydroxyethyl)-2-benzothiazolinone, was collected by filtration and air-dried at 25°-30° C. The product, mp. 90°-92° C. was obtained in 98% yield. After recrystallization from toluene, it melted at 94°-95° C. Anal. Calc'd for C9 H9 NO2 S: N, 7.17; S, 16.42; Found: N, 7.11; S, 16.12.
References:
US4210439,1980,A
