3-(2H-TETRAZOL-5-YL)BENZONITRILE synthesis

Yield:50907-33-0 99%

Reaction Conditions:

with sodium azide in N,N-dimethyl-formamide at 120; for 3 h;

Steps:

Typical procedure for the preparation of 5-substituted 1H-tetrazoles

General procedure: Cu(II)-NaY (0.1 g) was added to a mixture of benzonitrile (0.206 g, 2.0 mmol) and sodium azide (0.169 g, 2.6 mmol) in DMF (5 mL) and mixture was stirred at 120 °C for 3 h. After completion of reaction (as monitored by TLC), the catalyst was centrifuged, washed with ethyl acetate and the centrifugate was treated with ethyl acetate (30 mL) and 5 N HCl (20 mL) and stirred vigorously. The resultant organic layer was separated and the aqueous layer was again extracted with ethyl acetate (20 mL). The combined organic layers were washed with water and concentrated to give the crude solid crystalline 5-phenyltetrazole. The product was characterizedby ¹H NMR , ¹³C NMR and mass spectroscopic analysis.

References:

Sudhakar;Purna Chandra Rao;Prem Kumar;Suresh;Ravi [Asian Journal of Chemistry,2017,vol. 29,# 4,p. 864 - 866]