ChemicalBook CAS DataBase List 3,3,3-trifluoro-1-phenylpropan-1-ol

3,3,3-trifluoro-1-phenylpropan-1-ol synthesis

7synthesis methods

Product Name:3,3,3-trifluoro-1-phenylpropan-1-ol
CAS Number:2340-22-9
Molecular formula:C9H9F3O
Molecular Weight:190.16

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Yield:2340-22-9 100%

Reaction Conditions:

with C₁₇H₂₈ClIrN₂OS;hydrogen;sodium methylate in methanol at 40 - 42; under 18751.9 Torr; for 3 h;Reagent/catalyst;

Steps:

10 Example 10. Catalytic Hydrogenation of Aromatic Ketones (Scheme 16).

The results are summarized in Table 3. Again, the results are focusing on two iridium complexes to verify the effect of methylation of the NH ligand. (0609) (0610) Scheme 16. (0611) Table 3. Catalytic Hydrogenation of Aromatic Ketones.' (0612) Run cat subs S/C MeONa, Solv time, h temp, conv. yield, mol % °C %^b %^b l^c N-4 Kl 5 000 5 MeOH 0.5^d 40-41 100 100 (0613) 2^C N-5 Kl 5 000 5 MeOH 0.5^d 40 100 100 (0614) 3^C N-4 Kl 50 000 5 MeOH 3 40-41 58 58 (0615) 4^C N-5 Kl 50 000 5 MeOH 3 40 >99 >99 (0616) 5 N-4 K2 50 000 5 MeOH 3 40-42 9 9 (0617) 6 N-5 K2 50 000 5 MeOH 3 40 26 26 (0618) 7 N-4 K3 1 000 5 MeOH 1 40 >99 >99 (0619) 8 N-5 K3 1 000 5 MeOH 1 40 >99 >99 (0620) 9 N-4 K3 50 000 5 MeOH 3 40-42 25 25 (0621) 10 N-5 K3 50 000 5 MeOH 3 40-42 27 27 (0622) 11 N-4 K4 50 000 5 MeOH 3 40-43 ~0 ~0 (0623) 12 N-5 K4 50 000 5 MeOH 3 40-43 ~0 ~0 (0624) 13 N-4 K5 1 000 5 MeOH 3 40 ~0 ~0 (0625) 14 N-5 K5 1 000 5 MeOH 3 40 ~0 ~0 (0626) 15 N-4 K6 1 000 5 MeOH 3 40-42 100 100 (0627) 16 N-5 K6 1 000 5 MeOH 3 40-42 100 100 (0628) Standard reaction conditions: substrate (10 mmol), solvent (5 mL), 50 mL Parr autoclave. *NMR (1H or ¹⁹F, rd = 10 s). ^cEach run performed at least twice, see SI for details. ^Essentially completed after 20 min based on drop in pressure.