3,3,3-trifluoro-2,2-diMethylpropanoyl chloride synthesis
- Product Name:3,3,3-trifluoro-2,2-diMethylpropanoyl chloride
- CAS Number:1163707-53-6
- Molecular formula:C5H6ClF3O
- Molecular Weight:174.55
889940-13-0
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1163707-53-6
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Yield:-
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20;Product distribution / selectivity;
Steps:
64.4
Step 64.4: 3,3,3-Trifluoro-2,2-dimethyl-propionic acid butyl ester ); 3,3,3-Trifluoro-2,2-dimethyl-propionic acid (3.0 g, 19.2 mmol) and a drop of DMF are dissolved in 30 ml. of DCM and treated dropwise at RT with oxalyl chloride (1.85 ml_, 21.1 mmol). After 2 h gas evolution ceases and the mixture is treated slowly with triethyl amine (5.36 ml_, 38.4 mmol) followed by n-butanol (2.1 ml_, 23 mmol). The mixture is stirred over night, the solvent evaporated and the residue stirred with hexanes. The solid is filtered off and the filtrate is evaporated to a brown-red oil. Kugelrohr distillation (10 mbar, 60-80 0C oven temperature) gives the title compound a colorless liquid.
References:
NOVARTIS AG;CARAVATTI, Giorgio;FAIRHURST, Robin Alec;FURET, Pascal;GUAGNANO, Vito;IMBACH, Patricia WO2010/29082, 2010, A1 Location in patent:Page/Page column 104
79-37-8
492 suppliers
$17.67/10gm:
889940-13-0
173 suppliers
$25.00/250mg
1163707-53-6
15 suppliers
$558.46/1gm: