3,3,5,5-Tetramethyl-morpholine synthesis
- Product Name:3,3,5,5-Tetramethyl-morpholine
- CAS Number:19412-12-5
- Molecular formula:C8H17NO
- Molecular Weight:143.23
![2-[(1-HYDROXY-2-METHYLPROPAN-2-YL)AMINO]-2-METHYLPROPAN-1-OL](/CAS/20150408/GIF/44982-72-1.gif)
44982-72-1
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19412-12-5
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Yield:19412-12-5 50%
Reaction Conditions:
with sodium hydroxide;methanesulfonic acid
Steps:
5.A A.
A. Preparation of 3,3,5,5-tetramethyl-morpholine. STR13 3.0 g of di-(1-hydroxy-2-methyl-2-propyl)amine and 25 ml of methanesulfonic acid are placed in a round-bottomed flask and heated to 130° C. for more than 10 hr after which the reaction mixture is cooled down and added slowly to a 10% NaOH solution. The mixture is then extracted with 50 ml aliquots of methylene chloride several times, dried and concentrated. Upon distillation, a colorless oil is obtained in about 50% yield which boils at 63°-4° C./19 mm. It is found to be an excellent u-v stabilizer, as is evident from the data in Table I. Analysis by proton nuclear magnetic resonance (nmr) and field desorption (FD) mass spectroscopy confirms the structure of the oil as being 3,3,5,5-tetramethyl-morpholine.
References:
US4914232,1990,A US4528370,1985,A
90032-83-0
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19412-12-5
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