3,3'-Bipyridine-5-carboxylic acid synthesis
- Product Name:3,3'-Bipyridine-5-carboxylic acid
- CAS Number:1970-81-6
- Molecular formula:C11H8N2O2
- Molecular Weight:200.19
113893-00-8
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1970-81-6
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Yield:1970-81-6 55.9%
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran at 0; for 0.5 h;
Steps:
5-(3-Pyridyl)pyridine-3-carboxylic acid
Intermediate 70 (1.78g, 8.30mmol) was dissolved in THF (10mL) and water (10mL), cooled to 0°C, LiOH (522mg, 12.5mmol) was added, and stirred for 30min. The organics were evaporated, the aqueous phase was diluted with water (20mL), and washed with EtOAc (20mL). The aqueous phase was acidified with aq KHS04 (1M) until pH~4, the precipitate was collected by filtration, and washed with water to give the title compound (929mg, 55.9% ) as a white solid. LCMS (ES+): 201.1 [MH]+. UPLC: Rt 1.20min, 100% purity.
References:
WO2021/48567,2021,A1 Location in patent:Page/Page column 63
![[3,3'-Bipyridine]-5-carboxylic acid, ethyl ester](/CAS/20210305/GIF/484673-69-0.gif)
484673-69-0
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1970-81-6
38 suppliers
$68.00/100mg
20986-40-7
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$6.00/10g
1970-81-6
38 suppliers
$68.00/100mg
1692-25-7
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1970-81-6
38 suppliers
$68.00/100mg