3-(3-Chloro-5-fluorophenyl)benzonitrile synthesis
- Product Name:3-(3-Chloro-5-fluorophenyl)benzonitrile
- CAS Number:1345732-63-9
- Molecular formula:C13H7ClFN
- Molecular Weight:231.65
69113-59-3
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Yield:1345732-63-9 91%
Reaction Conditions:
Stage #1: 1-fluoro-3,5-dichlorobenzenewith magnesium;ethylene dibromide;lithium chloride in tetrahydrofuran at 25; for 0.75 h;
Stage #2: with zinc(II) chloride in tetrahydrofuran at 25;
Stage #3: 3-iodobenzonitrilewith trifuran-2-yl-phosphane;bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran at 25; for 2 h;
References:
Dunst, Cora;Knochel, Paul [Synlett,2011,# 14,art. no. S03411ST,p. 2064 - 2068] Location in patent:experimental part