ChemicalBook CAS DataBase List 3,3-DICHLORO-1,1,1-TRIFLUOROPROPANE

3,3-DICHLORO-1,1,1-TRIFLUOROPROPANE synthesis

13synthesis methods

Product Name:3,3-DICHLORO-1,1,1-TRIFLUOROPROPANE
CAS Number:460-69-5
Molecular formula:C3H3Cl2F3
Molecular Weight:166.96

3607-78-1
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460-69-5
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Yield:460-69-5 85 %

Reaction Conditions:

with hydrogen fluoride;CrF₃/C;nickelFlow reactor;Large scale;Reagent/catalyst;

Steps:

1-2; 1 (Example 1)

A device consisting of a nickel evaporator (40A×20 cm) and a nickel catalyst column (40A×150 cm) filled with 1.1 kg of 17wt%_CrF3-activated carbon catalyst was heated to 250 ° C. and the catalyst tower to an internal temperature of 190 ° C. Thereafter, while HF was flowed at 0.24 kg / h (11.8 mol / h, 3.6 eq), 1,1,1,3,3,3-hexachloropropane (HCP) was supplied to the evaporator at a setting of 9.03 ml / min (= 0.84 kg / h (3.35 mol / h)) and vaporized in the evaporator, and the mixture of HCP and HF was aerated into the catalyst tower to react. After aeration of 64.3 kg of 1,1,1,3,3,3-hexachloropropane, an organic layer containing HCFO-1223za at a rate of 93.2% by weight was obtained from a water trap at a yield of 38.8 kg with a yield of 85%. Thereafter, after supplying 369.6 kg of 1,1,1,3,3,3-hexachloropropane (HCP), the evaporator was inspected open, and no polymer was found.

References:

JP2023/56213,2023,A Location in patent:Paragraph 0026-0028