3-(3-METHOXYPHENYL) PIPERIDINE HYDROCHLORIDE synthesis

Yield:-

Reaction Conditions:

with hydrogenchloride;sodium hydroxide;PtO₂ in methanol;

Steps:

I.8 3-(3-Methoxyphenyl)piperidine hydrochloride (Method A2 and h)

Example I8. 3-(3-Methoxyphenyl)piperidine hydrochloride (Method A2 and h) To a solution of 3-(3-pyridinyl)methoxybenzene (22.0 g, 0.099 mol) in methanol (250 ml), PtO₂ (2 g) and conc. HCl (30 ml) were added and the mixture was hydrogenated at 0.34 MPa in a Parr apparatus. After complete hydrogenation, the catalyst was filtered off Most of the solvent was evaporated, the residue was made alkaline with 1M NaOH and extracted with ether. The ether-phase was dried (Na₂ SO₄) and the solvent evaporated giving 18 g of the amine product. The hydrochloride was made and then recrystallized from ethanol/ether yielding 20.9 g (93%), mp. 137-138.5° C.

References:

US4937346,1990,A