3-(3-N-Boc-aMinopropoxy)aniline synthesis
- Product Name:3-(3-N-Boc-aMinopropoxy)aniline
- CAS Number:1175649-60-1
- Molecular formula:C14H22N2O3
- Molecular Weight:266.34
![Carbamic acid, N-[3-(3-nitrophenoxy)propyl]-, 1,1-dimethylethyl ester](/CAS/20210111/GIF/1035452-25-5.gif)
1035452-25-5
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1175649-60-1
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Yield:1175649-60-1 88%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol at 20; for 16 h;
Steps:
62.3
To a solution of 4 (1.20 g, 4.05 mmol) in ethanol (25 mL)) was added Pd/C (0.12 g, 10% w/w) and the reaction mixture was allowed to stir under H2 atmosphere (1.5 Kg hydrogen pressure) at rt for 16 h. The reaction mixture was filtered through a pad of Celite and concentrated under reduced pressure to get 5 (0.95 g, 88%) as a brownish viscous oil. It was used in the next step without further purification.
References:
WO2009/158571,2009,A1 Location in patent:Page/Page column 238; 239
58885-58-8
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112663-43-1
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