3-{[3-(TRIFLUOROMETHYL)BENZYL]OXY}BENZALDEHYDE synthesis
- Product Name:3-{[3-(TRIFLUOROMETHYL)BENZYL]OXY}BENZALDEHYDE
- CAS Number:343604-08-0
- Molecular formula:C15H11F3O2
- Molecular Weight:280.24
99-06-9
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402-23-3
260 suppliers
$6.00/1g
343604-08-0
21 suppliers
$60.00/100mg
Yield:343604-08-0 79%
Reaction Conditions:
with potassium carbonate at 80; for 3 h;
Steps:
5.1 (1) 3 - (3 - trifluoromethyl-benzyloxy) benzaldehyde preparation
The 3 - hydroxybenzaldehyde (1.0 g, 8.2 mmol) dissolved in 15 ml DMF in, adding 3 - trifluoromethyl [...] (2.15 g, 9.0 mmol), potassium carbonate (1.35 g, 9.8 mmol), 80 °C reaction 3 hours, adding 15 ml distilled water, extracted with ethyl acetate twice (2 × 20 ml), then saturated sodium chloride solution for washing 1 time, dried with anhydrous sodium sulfate. Concentrated, column chromatography, eluting agent is petroleum ether: ethyl acetate=3:1, shall be transparent oil to 1.82 g, yield 79%.
References:
CN107151220,2017,A Location in patent:Paragraph 0127; 0128; 0129; 0130; 0131
100-83-4
654 suppliers
$5.00/10g
402-23-3
260 suppliers
$6.00/1g
343604-08-0
21 suppliers
$60.00/100mg
402-23-3
260 suppliers
$6.00/1g
343604-08-0
21 suppliers
$60.00/100mg