3,4,5-trimethoxy-N-(2-nitrophenyl)benzamide synthesis
- Product Name:3,4,5-trimethoxy-N-(2-nitrophenyl)benzamide
- CAS Number:3940-81-6
- Molecular formula:C16H16N2O6
- Molecular Weight:332.31
Yield:3940-81-6 65%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 70; for 7 h;Inert atmosphere;Cooling with ice;
Steps:
1.2 Synthesis of intermediate B
ake 690mg (5mmo 1) o-nitroaniline, add 1 OmL THF, 4mL triethylamine, add 15mmo 1 intermediate A (dropwise, produce a large amount of white solid and white smoke) in the ice bath, , Solidified at 70 ° C under nitrogen, reacted for 7 h, poured into water, the solid was precipitated and the solid was filtered. The solid was recrystallized from ethanol / water (1: 1) and filtered to give 1050 mg of intermediate B (3,4,5-trimethoxy Benzoyl-2-nitroaniline) as a brown flocculent crystal in 65%.
References:
CN104072425,2016,B Location in patent:Paragraph 0071-0072
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