3-(4-BROMOPHENYL)-5-P-TOLYL-1,2,4-OXADIAZOLE synthesis
- Product Name:3-(4-BROMOPHENYL)-5-P-TOLYL-1,2,4-OXADIAZOLE
- CAS Number:587006-12-0
- Molecular formula:C15H11BrN2O
- Molecular Weight:315.16
13222-85-0
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19227-14-6
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$15.00/1g
587006-12-0
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$100.00/1g
Yield:587006-12-0 76%
Reaction Conditions:
in water; for 12 h;Reflux;
Steps:
General procedure for the preparation of 1,2,4-oxadiazole 3
General procedure: The amidoxime (10 mmol) and anhydride (11 mmol) was added to water (20 mL) and the solution was stirred for 12 h at reflux. After stirring, the reaction mixture was washed with diethyl ether (3x50 mL). The resulting mixture was subjected to column chromatography on silica gel with EtOAc/n-hexane (1:9) and evaporation of the solvent under reduced pressure gave pure products in 35-93% yields. All products gave satisfactory spectral data in accord with the assigned structures.
References:
Kaboudin, Babak;Malekzadeh, Leila [Tetrahedron Letters,2011,vol. 52,# 48,p. 6424 - 6426] Location in patent:supporting information; experimental part
623-00-7
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587006-12-0
15 suppliers
$100.00/1g