3,4-DICHLOROBENZYL ISOCYANIDE synthesis

Yield:-

Reaction Conditions:

with methoxycarbonylsulfamoyl-triethylammmonium hydroxide in acetonitrile at 50; for 3 h;

Steps:

S.ii

To N-(3,4-dichlorobenzyl)formamide (from step (i) above) (245 mg, 1.20 mmol) dissolved in MeCN (6 mL) was added (methoxycarbonylsulfamoyl)triethylammonium hydroxide, inner salt (Burgess reagent) (286 mg, 1.20 mmol). The mixture was stirred at 50° C. for 3 h. After cooling to rt, the mixture was transferred directly to the next reaction step without any work-up.

References:

US2008/15237,2008,A1 Location in patent:Page/Page column 32