ChemicalBook CAS DataBase List 3,4-DICHLOROPHENETHYLAMINE

3,4-DICHLOROPHENETHYLAMINE synthesis

7synthesis methods

Product Name:3,4-DICHLOROPHENETHYLAMINE
CAS Number:21581-45-3
Molecular formula:C8H9Cl2N
Molecular Weight:190.07

3218-49-3 Synthesis

3218-49-3
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$5.00/5g

21581-45-3
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$19.00/1g

Yield:21581-45-3 92%

Reaction Conditions:

with ammonia;hydrogen;nickel in ethanol;water; under 760.051 Torr; for 6 h;

Steps:

A

Method A. A solution of 3,4-dichlorophenylacetonitrile (3.001 g, 16.13 mmol) in ethanol (33 mL) and 29% NH₄OH (6.7 ml, 611.2 mg, 17.44 mmol) in the presence of Raney Ni (333 mg, 3.887 mmol) was stirred vigorously under H₂ (1 atm) for 6 h. The reaction mixture was filtered through Celite then the filtrate was concentrated under reduced pressure to give 2-(3,4-dichlorophenyl)ethylamine (2.82 g, 92%) as a pale yellow oil. LC/MS ((10%-99% CH₃CN (0.035% TFA)/H₂O (0.05% TFA)), m/z: M+1 obs=190.3; t_r=0.80 min.

References:

US2009/124655,2009,A1 Location in patent:Page/Page column 27-28