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ChemicalBook CAS DataBase List 3,4-Diethoxyaniline
39052-12-5

3,4-Diethoxyaniline synthesis

5synthesis methods
3,4-DIETHOXY NITROBENZENE

4992-63-6

3,4-Diethoxyaniline

39052-12-5

The general procedure for the synthesis of 3,4-diethoxyaniline from 3,4-diethoxynitrobenzene was as follows: 3,4-diethoxynitrobenzene (6.30 g, 29.9 mmol), 10% palladium-carbon catalyst (600 mg), and anhydrous ethanol (300 mL) were added to a reaction flask, and the reaction was stirred for 6 hours under hydrogen atmosphere. Upon completion of the reaction, the insoluble palladium-carbon catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 3,4-diethoxyaniline as an oily product in a yield of 5.02 g (92.9% yield). The product was characterized by 1H-NMR (CDCl3) with chemical shifts δ: 1.34 to 1.46 (6H, m), 3.94 to 4.08 (4H, m), 6.21 (1H, d, J = 2.8,8.4 Hz), 6.30 (1H, d, J = 2.6 Hz), 6.73 (1H, d, J = 8.4 Hz).

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Yield: 92.9%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in ethanol for 6 h;

Steps:

68.2 (2)
3,4-Diethoxy aniline
A solution of 1, 2-ethoxy-4-nitrobenzene (6.30 g, 29.9 mmol), 10% palladium carbon (600 mg) and ethanol (300 ML) was stirred under hydrogen atmosphere for 6 hours.. The insolubles were filtered off, and the filtrate was concentrated, to obtain the titled compound as oil. 5.02 g (92.9%) 1H-NMR (CDCl3) δ; 1.34 to 1.46 (6H, m), 3.94 to 4.08 (4H, m), 6.21 (1H, d, J = 2.8, 8.4Hz), 6.30 (1H, d, J = 2.6 Hz), 6.73 (1H, d, J = 8.4 Hz)

References:

Takeda Chemical Industries, Ltd. EP1437344, 2004, A1 Location in patent:Page 37

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