Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 3,4-DIFLUOROPHENETOLE

3,4-DIFLUOROPHENETOLE synthesis

2synthesis methods
-

Yield:163848-46-2 92.1%

Reaction Conditions:

with tetramethlyammonium chloride;sodium hydroxide in water;N,N-dimethyl-formamide;toluene at 30;Reflux;Industrial scale;

Steps:

4 Preparation of 3,5-difluorophenyl ethyl ether

1000L reactor was charged with sodium hydroxide 40kg, 500kg toluene, 3,4-difluoro-phenol 100kg, Bi administered warmed to reflux trap by trap until no expulsion of water up to give 3,4-difluoro sodium phenoxide. Then cooling to 5kg tetramethylammonium chloride was added after 30 , DMF5kg, plus complete solution of bromoethane 90kg, dropping Albert warmed to reflux incubation reaction to the raw material disappears. After passing cooling to 30 , filtered and the filtrate washed twice 100kg of water was added, layers were separated and the organic layer is a toluene solution of 3,4-difluorophenyl ether. Recovered by distillation of toluene, and then the tower distillation, the product 3,4-difluorophenyl ether 112kg, GC content of> 99.9% and a yield of 92.1%

References:

CN104529723,2016,B Location in patent:Paragraph 0045-0047

3,4-DIFLUOROPHENETOLE Related Search: