3,4-dihydro-2H-1,4-benzoxazin-6-ol synthesis
- Product Name:3,4-dihydro-2H-1,4-benzoxazin-6-ol
- CAS Number:26021-57-8
- Molecular formula:C8H9NO2
- Molecular Weight:151.16
53412-38-7
38 suppliers
$65.00/100mg
26021-57-8
108 suppliers
$72.00/100mg
Yield:26021-57-8 100%
Reaction Conditions:
with borane-THF in tetrahydrofuran at 0 - 20;
Steps:
d
Compound 48 (0.39 g, 2.35 mmol) was dissolved in THF and IM BH3-THF (7.05 ml, 7.05 mmol) was added to the reaction mixture at 0 0C slowly over a time of 5 min. After the addition the reaction mixture was warmed to the room temperature and left overnight. Excess borane was destroyed by careful addition of methanol. The solvent was removed and the crude reaction mixture was extracted in EtOAc to give an oily pure compound in quantitative yield (0.34 g.). 1H NMR(dmso-d6): 8.48 (s, IH), 6.37 (d, IH, J=8.47 Hz), 5.96 (d, IH, J=2.75 Hz), 5.82 (dd, IH, J=8.44, 2.76 Hz), 3.97 (t, 2H, J=4.38 Hz), 3.18 (t, 2H, J=4.31 Hz). 13C NMR (dmso-d6): 152.2, 136.6, 135.8, 116.7, 103.8, 102.0, 65.0, 47.2. ES- HRMS [M+H]+ 152.0711. Calcd for (C8Hi0NO2): 152.0711
References:
UNIVERSITY OF MASSACHUSETTS WO2009/36351, 2009, A2 Location in patent:Page/Page column 21; 22/24
28226-20-2
11 suppliers
$669.89/1G
26021-57-8
108 suppliers
$72.00/100mg
![6-METHOXY-3,4-DIHYDRO-2H-BENZO[B][1,4]OXAZINE](/CAS/GIF/58960-11-5.gif)
58960-11-5
53 suppliers
$90.00/50mg
26021-57-8
108 suppliers
$72.00/100mg
22158-78-7
27 suppliers
$60.00/100mg
26021-57-8
108 suppliers
$72.00/100mg
102-56-7
310 suppliers
$10.00/5g
26021-57-8
108 suppliers
$72.00/100mg