3,4-dihydro-6-methyl-7-nitro-1(2H)-Naphthalenone synthesis

Yield:1190892-51-3 50%

Steps:

R.127.A 6-methyl-7-nitro-3,4-dihydronaphthalen-1(2H)-one

Step A 6-methyl-7-nitro-3,4-dihydronaphthalen-1(2H)-one Using 6-methyl-3,4-dihydronaphthalen-1(2H)-one (4.74 g, 29.6 mmol) and according to the method of Reference Example 126, step A, the title compound (3.02 g, yield 50%) was obtained as a pale-yellow solid. ¹H-NMR (400 MHz, CDCl₃); δ(ppm) 2.14-2.21 (m, 2H), 2.63 (s, 3H), 2.67-2.71 (m, 2H), 3.00 (t, J=6.1, 2H), 7.25 (s, 1H), 8.61 (s, 1H).

References:

US2012/196824,2012,A1