3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER synthesis

9synthesis methods

Product Name:3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER
CAS Number:51828-89-8
Molecular formula:C12H12O3
Molecular Weight:204.22

1122-91-4
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3-(4-FORMYLPHENYL)-2-PROPENOIC ACID ETHYL ESTER

51828-89-8
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Yield:51828-89-8 99%

Reaction Conditions:

with C₂₆H₁₆Cl₂F₄N₄Pd;sodium carbonate in N,N-dimethyl acetamide at 140; for 10 h;Schlenk technique;Inert atmosphere;Heck Reaction;

Steps:

Heck reaction procedure

General procedure: A Schlenk flask was filled with the aryl halide (1.3 mmol),methyl acrylate (1.3 mmol), Na2CO3 (2.6 mmol), complex 3(0.0013 mmol), and DMA (1 mL) under a N2 atmosphere.The mixture was then heated at 140 °C for 10 h. After thereaction was complete, the solution was cooled to roomtemperature. The reaction mixture was then washed withwater, extracted with CH2Cl2 (3 × 5 mL), dried overNa2SO4, and filtered. The solvent was removed underreduced pressure. Further purification of the product wasachieved by flash chromatography on a silica gel column.

References:

Feng, Can;Liu, Cheng-Xin;Wang, Yu-Fang;Cui, Jin;Zhang, Ming-Jie [Journal of Chemical Research,2020,vol. 44,# 11-12,p. 684 - 688]

81172-89-6 Synthesis