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ChemicalBook CAS DataBase List 3,5-Dibromo-4-cyanopyridine, 97%

3,5-Dibromo-4-cyanopyridine, 97% synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 2 h / -70 - 0 °C / Inert atmosphere
1.2: 2 h / -70 °C
2.1: hydroxylamine hydrochloride; sodium carbonate / methanol; water / 2 h / 20 °C
3.1: bis(trichloromethyl) carbonate / N,N-dimethyl-formamide / 0.5 h

References:

Radiant Pharma & Tech. Co., Ltd.;HU, Yingjian;LUO, Zhibin;ZHANG, Yanhong;HAN, Li;WANG, Yun;LU, Hongfei US2016/207916, 2016, A1

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