3,5-dichlorobenzyl piperazine-1-carboxylate synthesis
- Product Name:3,5-dichlorobenzyl piperazine-1-carboxylate
- CAS Number:1144037-37-5
- Molecular formula:C12H14Cl2N2O2
- Molecular Weight:289.16
![1,4-Piperazinedicarboxylic acid, 1-[(3,5-dichlorophenyl)methyl] 4-(1,1-dimethylethyl) ester](/CAS/20200515/GIF/1144037-36-4.gif)
1144037-36-4
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1144037-37-5
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Yield:1144037-37-5 93.2 %
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20;
Steps:
3,5-dichlorobenzyl piperazine-1-carboxylate (35).
To a solution of 34 (1.95 g, 5.00 mmol) in CH2Cl2(10 mL)was added trifluoroacetic acid (5 mL).The reaction mixture was stirred at room temperature for 3 h.The solvent was evaporated to dryness.The product was neutralized with 1M K2CO3solution and extracted with ethyl acetate.The organic layer was dehydrated with anhydrous sodium sulfate and concentrated.The product was purified by amino column chromatography (hexane/ethyl acetate)to give 35 as a colorless oil (1.44 g, 93.2%).
References:
KR102502940,2023,B1 Location in patent:Paragraph 0400-0401; 0405-0407
60211-57-6
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1144037-37-5
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