3,5-dichlorobenzyl piperazine-1-carboxylate synthesis

3synthesis methods

Product Name:3,5-dichlorobenzyl piperazine-1-carboxylate
CAS Number:1144037-37-5
Molecular formula:C12H14Cl2N2O2
Molecular Weight:289.16

1,4-Piperazinedicarboxylic acid, 1-[(3,5-dichlorophenyl)methyl] 4-(1,1-dimethylethyl) ester

1144037-36-4
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3,5-dichlorobenzyl piperazine-1-carboxylate

1144037-37-5
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Yield:1144037-37-5 93.2 %

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20;

Steps:

3,5-dichlorobenzyl piperazine-1-carboxylate (35).

To a solution of 34 (1.95 g, 5.00 mmol) in CH₂Cl₂(10 mL)was added trifluoroacetic acid (5 mL).The reaction mixture was stirred at room temperature for 3 h.The solvent was evaporated to dryness.The product was neutralized with 1M K₂CO₃solution and extracted with ethyl acetate.The organic layer was dehydrated with anhydrous sodium sulfate and concentrated.The product was purified by amino column chromatography (hexane/ethyl acetate)to give 35 as a colorless oil (1.44 g, 93.2%).

References:

KR102502940,2023,B1 Location in patent:Paragraph 0400-0401; 0405-0407

60211-57-6 Synthesis

60211-57-6
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References

Carbonochloridic acid, (3,5-dichlorophenyl)methyl ester

1175526-48-3
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References