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ChemicalBook CAS DataBase List 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE
312736-50-8

3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE synthesis

1synthesis methods
2,6-Dichloropyrazine

4774-14-5

formamide

77287-34-4

3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE

312736-50-8

The general procedure for the synthesis of 3,5-dichloropyrazine-2-carboxamide from 2,6-dichloropyrazine and the compound (CAS:77287-34-4) was as follows: to a mixed solution containing 2,6-dichloropyrazine (11.0 g, 73.8 mmol) and formamide (58.6 mL, 1,476 mmol) was slowly added dropwise sodium persulfate (17.1 g, 71.7 mmol). The reaction mixture was stirred at 90 °C for 2 hours, followed by continued stirring at room temperature for 12 hours. After completion of the reaction, the reaction mixture was diluted with water and then extracted with isopropanol/chloroform (1:3, v/v) and the organic phase was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: 70% n-hexane/ethyl acetate) to afford 3,5-dichloropyrazine-2-carboxamide (5.06 g, 36% yield) as an oil.

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Yield:-

Reaction Conditions:

Stage #1:3,5-dichloropyrazine-2-carboxylic acid with thionyl chloride
Stage #2: with ammonia in dichloromethane

References:

YAMANOUCHI PHARMACEUTICAL CO. LTD. EP1184376, 2002, A1 Location in patent:Page 12

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