(3,5-DIFLUORO-2-METHOXYPHENYL)BORONIC ACID, 97 synthesis
- Product Name:(3,5-DIFLUORO-2-METHOXYPHENYL)BORONIC ACID, 97
- CAS Number:737000-76-9
- Molecular formula:C7H7BF2O3
- Molecular Weight:187.94
202865-59-6
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737000-76-9
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Yield: 228 mg
Reaction Conditions:
Stage #1:1-bromo-3,5-difluoro-2-methoxybenzene with n-butyllithium in tetrahydrofuran;diethyl ether at -78; for 0.0333333 h;
Stage #2: with Triisopropyl borate in tetrahydrofuran;diethyl ether at -78 - 20;
Stage #3: with hydrogenchloride in tetrahydrofuran;diethyl ether for 0.5 h;Further stages.;
References:
Jones, Lyn H.;Randall, Amy;Barba, Oscar;Selby, Matthew D. [Organic and Biomolecular Chemistry,2007,vol. 5,# 21,p. 3431 - 3433]