3,5-DIFLUOROBENZENESULFONAMIDE synthesis
- Product Name:3,5-DIFLUOROBENZENESULFONAMIDE
- CAS Number:140480-89-3
- Molecular formula:C6H5F2NO2S
- Molecular Weight:193.17
210532-25-5
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$10.00/5g
140480-89-3
115 suppliers
$11.00/1g
Yield: 88%
Reaction Conditions:
with ammonium hydroxide in tetrahydrofuran;water for 1 h;Cooling with ice;
Steps:
To a solution of 3,5-difluorobenzenesulfonyl chloride (25 g, 0.117 mol) in THF (150 mL) was added 35% aq. NH4OH (120 mL) over 1 h in an ice-bath. After the reaction was complete, it was evaporated in vacuo. To a solution of this residue in water (150 mL) was added 2N HC1 (1 mL). After stirring 1 h, the reaction mixture was filtered and dried under high vacuum to give 3,5-difluorobenzenesulfonamide as a light brown solid (19.9 g, 88%). 1H NMR (400MHz, CDC13) δ 7.49-7.44 (m, 2H), 7.04-6.99 (m, 2H).
References:
EXELIXIS, INC.;BOLLU, Venkataiah;BOREN, Brant, Clayton;DALGARD, Jackline;FLATT, Brenton, T.;HAQ, Nadia;HUDSON, Sarah;MOHAN, Raju;MORRISSEY, Michael;PRATT, Benjamin WO2011/71565, 2011, A1 Location in patent:Page/Page column 169
372-39-4
377 suppliers
$16.00/5g
140480-89-3
115 suppliers
$11.00/1g