3,6-dibroMopyrazine-2-carboxaMide synthesis
- Product Name:3,6-dibroMopyrazine-2-carboxaMide
- CAS Number:1301613-77-3
- Molecular formula:C5H3Br2N3O
- Molecular Weight:280.9
957230-68-1
68 suppliers
$35.00/1g
1301613-77-3
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$82.59/250mg
Yield:1301613-77-3 31 %
Reaction Conditions:
with ammonium chloride;N-ethyl-N,N-diisopropylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in N,N-dimethyl-formamide at 25;
Steps:
64.1 Step 1: 3,6-Dibromopyrazine-2-carboxamide
3,6-Dibromopyrazine-2-carboxylic acid (1.0 g, 3.55 mmol) in DMF (10 mL)To a solution of NHCl (570 mg, 10.6 mmol), HATU (1.62 g, 4.26 mmol)and DIEA (2.29 g, 17.7 mmol) were added and the mixture was stirred at 25 oC for 1 hour. The reaction mixture was diluted with aqueous ammonium chloride solution (20 mL) at 25 oC.was added to quench, then water (30 mL) was added and EA (50 mL x 3)was extracted with The combined organic layers were washed with brine (20 mL x 3), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography to give 3,6-dibromopyrazine-2-carboxamide (310 mg, 31% yield) as a yellow solid.
References:
WO2023/282702,2023,A1 Location in patent:Paragraph 688-691
13301-04-7
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$7.00/250mg
1301613-77-3
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$82.59/250mg
17890-77-6
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$10.00/250mg
1301613-77-3
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$82.59/250mg
32587-10-3
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$43.00/250mg
1301613-77-3
20 suppliers
$82.59/250mg
16298-03-6
337 suppliers
$7.00/1g
1301613-77-3
20 suppliers
$82.59/250mg