3,6-dichloropyrido[2,3-b]pyrazine synthesis
- Product Name:3,6-dichloropyrido[2,3-b]pyrazine
- CAS Number:1350925-22-2
- Molecular formula:C7H3Cl2N3
- Molecular Weight:200.02
![6-chloropyrido[3,2-b]pyrazin-3(4H)-one](/CAS/20180703/GIF/1350925-21-1.gif)
1350925-21-1
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Yield: 90%
Reaction Conditions:
with trichlorophosphate for 3 h;Reflux;
Steps:
E; 3.3e
6-chloropyrido[3,2-b]pyrazin-3(4H)-one (E-27) (9 g, 49.8 mmol) was dissolved in POCl3 (100 mL) and the resulting mixture was stirred at reflux for 3 h. The reaction was complete based on TLC analysis. The mixture was cooled to RT and concentrated in vacuo to remove POCI3. The residue was poured into ice water (150 mL) and extracted with DCM (3 χ 100 mL). The combined organic layers were washed with brine, dried over Na2S04 and filtered. The filtrate was concentrated in vacuo to give the desired product 3,6-dichloropyrido[2,3-b]pyrazine (E-28) (9 g, 90% yield) as a solid. ESI-MS m/z : 199.97 [M+H]+.
References:
INTELLIKINE, INC.;REN, Pingda;LIU, Yi;LI, Liansheng;CHAN, Katrina;WILSON, Troy, Edward;CAMPBELL, Simon, Fraser WO2011/149937, 2011, A1 Location in patent:Page/Page column 41; 85; 86
146015-42-1
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1350925-22-2
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40851-95-4
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$7.00/100mg
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1350925-19-7
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![6-chloro-1,2-dihydropyrido[2,3-b]pyrazin-3(4H)-one](/CAS/20180703/GIF/1350925-20-0.gif)
1350925-20-0
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1350925-22-2
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