(3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one synthesis
- Product Name:(3β,9β,10α)-3-Hydroxy-pregna-5,7-dien-20-one
- CAS Number:1819-14-3
- Molecular formula:C21H30O2
- Molecular Weight:314.4617
81968-78-7
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Yield:1819-14-3 40%
Reaction Conditions:
in tetrahydrofuran at 20; for 3 h;Irradiation;Solvent;Wavelength;
Steps:
7-10 Example 7.
16 grams of IIa dissolved in 2.0 liters of tetrahydrofuran,The solution was introduced into a glass reactor, at room temperature, 1500 watts high pressure mercury lamp (wavelength range is 290-330nm) continued to irradiate for three hours, flow out of the reaction solution under reduced pressure to distill tetrahydrofuran, add 100 ~ 300mL ether, and stir at room temperature for 10 Minutes, the solid is recovered by filtration (insoluble material is raw material IIa), the filtrate is washed with water (3X100 mL), a little activated carbon is added, dried with anhydrous sodium sulfate, and recrystallized from acetone to obtain 6.4 g of IIIa (40%, purity 99.7%).
References:
CN112812146,2021,A Location in patent:Paragraph 0020-0023
1778-02-5
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1819-14-3
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28319-79-1
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