(3-ACETAMIDO-2-NITRO)BENZENEBORONIC ACID synthesis
- Product Name:(3-ACETAMIDO-2-NITRO)BENZENEBORONIC ACID
- CAS Number:78887-38-4
- Molecular formula:C8H9BN2O5
- Molecular Weight:223.98
78887-38-4
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![B-[3-(Acetylamino)-2-aminophenyl]boronic acid](/CAS/20210305/GIF/956580-14-6.gif)
956580-14-6
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Yield:-
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethanol at 20; under 760.051 Torr; for 0.333333 h;
Steps:
5.1
10 % Pd on carbon (cat.) was added as a slurry in EtOH under N2 to [3-(acetylamino)-2- nitrophenyljboronic acid in EtOH (0.05 M). The atmosphere in the reaction vessel was flushed with hydrogen (1 atm) and the reaction stirred vigorously at RT for 20 min. The hydrogen atmosphere was then replaced with N2 before filtering through a plug of celite - washing well with EtOH. The EtOH solution was concentrated in vacuo to afford the crude title compound as a brown solid, which was used immediately in the subsequent cross-coupling step. MS (ES+) m/z 195 (M+H)+.
References:
WO2007/129119,2007,A1 Location in patent:Page/Page column 33
78887-38-4
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$85.00/25mg
78887-35-1
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