3-ACETYL-6-NITRO-4-PHENYLQUINOLIN-2(1H)-ONE synthesis
- Product Name:3-ACETYL-6-NITRO-4-PHENYLQUINOLIN-2(1H)-ONE
- CAS Number:202192-77-6
- Molecular formula:C17H12N2O4
- Molecular Weight:308.29
Yield:202192-77-6 88.6%
Reaction Conditions:
at 180; for 5 h;
Steps:
1.3 (3) Preparation of Intermediate 5
Place 2-amino-5nitrobenzophenone (compound 4, 24.2g, 0.1mol) in 500ml round bottom simmer, add ethyl acetoacetate (39.0g, 0.3mol), and react at 180°C under reflux for 5 hours , After the reaction, the temperature was lowered to room temperature and slowly poured into 300ml of ice water while stirring. After the gelatinous precipitate became firm, filtered and washed with water for 2-3 times to obtain product 5 (27.3g, yield: 88.6%) .
References:
CN112390750,2021,A Location in patent:Paragraph 0028; 0037-0040
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