3-Azaspiro[5.5]undecane-9-acetic acid methyl ester synthesis
- Product Name:3-Azaspiro[5.5]undecane-9-acetic acid methyl ester
- CAS Number:1017623-70-9
- Molecular formula:C13H23NO2
- Molecular Weight:225.33
![3-Azaspiro[5.5]undecane-9-acetic acid, 3-[(1,1-diMethylethoxy)carbonyl]-, Methyl ester](/CAS/GIF/1346229-41-1.gif)
1346229-41-1
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Yield:-
Reaction Conditions:
with hydrogenchloride;methanol in 1,4-dioxane at 20; for 3 h;
Steps:
1.D Step D Methyl 2-(3-azaspiro[5.5]undecan-9-yl)acetate
To a round bottom flask was added the title compound from Example 1 Step C (20 g, 61.4 mmol) in MeOH (120ml), and then 4 M HCl in dioxane (48 mL) was added. The mixture was stirred at ambient temperature for 3 h. The solvent was removed under reduced pressure to afford an off-white solid as crude product. To the crude product was added saturated NaHCO3 until basic. The water layer was extracted with DCM (2 x 300 niL), the organic layer was combined and washed with brine and dried over Na2S04, filtered and dried down to afford the title compound that was used directly for next step.
References:
WO2014/59232,2014,A2 Location in patent:Page/Page column 40
![3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-oxo-, phenylMethyl ester](/CAS/GIF/189333-18-4.gif)
189333-18-4
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1017623-70-9
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138163-08-3
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$6.00/1g
1017623-70-9
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![3-Azaspiro[5.5]undec-7-ene-3-carboxylic acid, 9-(2-methoxy-2-oxoethylidene)-, phenylmethyl ester](/CAS/20210305/GIF/1599478-96-2.gif)
1599478-96-2
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1017623-70-9
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