3-BROMO-3',5'-DIFLUOROBENZOPHENONE synthesis
- Product Name:3-BROMO-3',5'-DIFLUOROBENZOPHENONE
- CAS Number:844879-37-4
- Molecular formula:C13H7BrF2O
- Molecular Weight:297.09
874889-34-6
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844879-37-4
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Yield:844879-37-4 38%
Reaction Conditions:
Stage #1: 1,3-dibromobenzenewith iodine;magnesium in diethyl ether at 20 - 30;Inert atmosphere;
Stage #2: 3,5-difluoro-N-methoxy-N-methylbenzamide in diethyl ether at 0 - 20;Inert atmosphere;
References:
Kishore Kumar;Chavarria, Gustavo E.;Charlton-Sevcik, Amanda K.;Arispe, Wara M.;MacDonough, Matthew T.;Strecker, Tracy E.;Chen, Shen-En;Siim, Bronwyn G.;Chaplin, David J.;Trawick, Mary Lynn;Pinney, Kevin G. [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 4,p. 1415 - 1419] Location in patent:supporting information; experimental part