3-bromo-5-chloro-2-methoxybenzaldehyde synthesis
- Product Name:3-bromo-5-chloro-2-methoxybenzaldehyde
- CAS Number:25299-26-7
- Molecular formula:C8H6BrClO2
- Molecular Weight:249.49
19652-32-5
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74-88-4
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25299-26-7
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Yield:25299-26-7 98%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 50; for 14 h;
Steps:
122.A
3-Bromo-5-chloro-2-hydroxybenzaldehyde (2 g, 8.5 mmol, 1 eq) was dissolved in DMF (10 mL) and treated with potassium carbonate (1.76 g, 12.7 mmol, 1.5 eq) and iodomethane (1.06 mL, 17 mmol, 2 eq) y The mixture was stirred at 50° C. for 14 h. The mixture was poured into water (100 mL) and extracted with ether (2×75 mL). The ether layers were washed successively with 15% aqueous NaOH, water, and then brine (50 mL each). Drying over magnesium sulfate and concentration in vacuo gave the ether 322 as a white solid (2.07 g, 98% yield).
References:
US2008/114167,2008,A1 Location in patent:Page/Page column 232
871339-17-2
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25299-26-7
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65851-97-0
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25299-26-7
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