3-broMo-5h-cyclopenta[b]pyridin-7(6h)-one synthesis
- Product Name:3-broMo-5h-cyclopenta[b]pyridin-7(6h)-one
- CAS Number:1336955-89-5
- Molecular formula:C8H6BrNO
- Molecular Weight:212.04
![3-broMo-6,7-dihydro-5h-cyclopenta[b]pyridin-7-ol](/CAS/20150408/GIF/1379342-51-4.gif)
1379342-51-4
21 suppliers
$468.00/1g
1336955-89-5
28 suppliers
$45.00/2.5mg
Yield:1336955-89-5 85%
Reaction Conditions:
with 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide at 20; for 2 h;
Steps:
3-Bromo-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (42):
To a solution of 3-bromo-6,7-dihydro-5H-cyclopenta[b]pyridin-7-ol (41, 1.52 g, 7.08 mmol) in DMSO(10 mL) was added IBX (3.96 g, 14.16 mmol). The mixture was at room temperaturefor 2 h, quenched with water (70 mL), and extracted with ethyl acetate. The organiclayers were combined, washed with brine, and concentrated. The residue was purifiedby silica gel column chromatography to afford 42 (1.27 g, 85%).
References:
Dai, Hongjuan;Feng, Li;Jiang, Cheng;Li, Xue;Wang, Hai;Wang, Yazhou;Yang, Shengwei;Yu, Shujia;Zhao, Liwen [Molecules,2021,vol. 26,# 11] Location in patent:supporting information
1379342-51-4
21 suppliers
$468.00/1g
87413-09-0
526 suppliers
$10.64/1G
1336955-89-5
28 suppliers
$45.00/2.5mg
![Cyclopenta[b]pyridine](/CAS/GIF/533-37-9.gif)
533-37-9
341 suppliers
$6.00/5g
1336955-89-5
28 suppliers
$45.00/2.5mg