3-Bromo-6-chloro-2-fluorobenzylbromide synthesis

Yield:886615-32-3 30%

Reaction Conditions:

with phosphorus tribromide in dichloromethane at 0; for 0.333333 h;

Steps:

9

Preparation 9; 1 -bromo- 3 -bromomethyl -4-chloro-2-fluorobenzene; Add phosphorous tribromide (1.8 mL, 19.2 mmol) to (3-bromo-6-chloro-2-fluoro- phenyl)methanol (Preparation 8) (4.6 g, 19 mmol) in dichloromethane (50 mL) at O⁰C. Stir for 20 minutes. Add the reaction mixture into ice and water. Extract with dichloromethane (100 mL), dry with magnesium sulfate, filter and evaporate solvent under reduced pressure. Purify the residue by biotage chromatography to yield the product to give 1.7 g (30 %) of the title compound as a white solid.

References:

WO2006/49952,2006,A1 Location in patent:Page/Page column 54