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ChemicalBook CAS DataBase List 3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE
143591-61-1

3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE synthesis

2synthesis methods
8-Chloro-imidazo[1,2-a]pyrazine

69214-33-1

3-BROMO-8-CHLOROIMIDAZO[1,2-A]PYRAZINE

143591-61-1

General procedure for the synthesis of 3-bromo-8-chloroimidazo[1,2-a]pyrazine from 8-chloroimidazo[1,2-a]pyrazine: N-bromosuccinimide (1.78 g, 10 mmol) was added to a solution of 8-chloroimidazo[1,2-a]pyrazine (1.53 g, 10 mmol) in dichloromethane (30 mL), and the reaction was stirred for 2 hours at room temperature. After the reaction was completed, the reaction mixture was washed with saturated aqueous sodium carbonate solution (2×20 mL), dried with anhydrous magnesium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 3-bromo-8-chloroimidazo[1,2-a]pyrazine (2.11 g, 96% yield).

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Yield:143591-61-1 96%

Reaction Conditions:

with N-Bromosuccinimide in dichloromethane at 20; for 2 h;

Steps:


To a solution of 8-chloro-imidazo[l,2-a]pyrazine (1.53 g, 0.01 mol) in DCM (30 mL) is added N-bromosuccinimide (1.78 g, 0.01 mol) and the reaction is stirred at room temperature for 2h. After this time the solution is washed with saturated aqueous solution of Na2CO3 (2 x 20 mL), dried (MgSO4), filtered and concentrated in vacuo to give 3-bromo-8-chloro-imidazo[l,2- a]pyrazine (2.11 g, 96%).

References:

BIOFOCUS DPI LIMITED WO2009/24585, 2009, A2 Location in patent:Page/Page column 46

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