3-CHLORO-1,7-NAPHTHYRIDIN-8(7H)-ONE synthesis
- Product Name:3-CHLORO-1,7-NAPHTHYRIDIN-8(7H)-ONE
- CAS Number:1393575-76-2
- Molecular formula:C8H5ClN2O
- Molecular Weight:180.59
1627895-51-5
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Yield:1393575-76-2 1.1 g
Reaction Conditions:
with toluene-4-sulfonic acid in benzene at 80;Sonication;
Steps:
5.4 3-Chloro-1,7-naphthyridin-8(7H)-one
To a solution of this intermediate (1.8 g, 7.36 mmol) in benzene (20 mL) was added p-toluenesulfonic acid (0.350 g, 1.839 mmol) and the reaction was sonicated for 10 minutes. The solution was stirred overnight at 80° C. and concentrated. The crude product was purified via silica gel, eluting with 0-100% (80/20/1 ethyl acetate/methanol/ammonium hydroxide) in ethyl acetate, to the title intermediate (1.1 g, 6.1 mmol). MS m/z=181 (M+H)
References:
US2014/213581,2014,A1 Location in patent:Paragraph 0606
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137628-17-2
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