3-CHLORO-4-(PHENETHYLOXY)ANILINE synthesis

Yield:80019-76-7 91.03%

Reaction Conditions:

with iron;ammonium chloride in ethanol at 80; for 3 h;

Steps:

91.b b) 3-chloro-4-phenethoxyaniline

Dissolve ammonium chloride (2.08 g, 38.88 mmol) in water (10 mL), add it to a turbid solution of iron powder (726 mg, 12.96 mmol) in ethanol (30 mL), stir to 80 ° C, and add 1-phenylethoxyl A solution of methyl-2-chloro-4-nitrobenzene (1.2 g, 4.32 mmol) in ethanol (10 mL), reacted at reflux for 3 h, cooled to room temperature, filtered through celite, concentrated the filtrate, and added EA (20 mL) to dissolve the residue. It was washed with saturated brine (20 mL × 3), washed with water (20 mL × 2), dried over anhydrous magnesium sulfate, and subjected to column chromatography (P / E = 5: 1) to obtain 974 mg as a yellow oil with a yield of 91.03%.

References:

CN110483366,2019,A Location in patent:Paragraph 1316; 1322-1324