3-Chloro-6-hydrazinopyridazine synthesis
- Product Name:3-Chloro-6-hydrazinopyridazine
- CAS Number:17284-97-8
- Molecular formula:C4H5ClN4
- Molecular Weight:144.56
141-30-0
17284-97-8
General procedure for the synthesis of 3-chloro-6-hydrazinopyridazine from 3,6-dichloropyridazine: 3,6-dichloropyridazine (3 g, 20.14 mmol) was reacted with hydrazine monohydrate (1 g, 20.14 mmol) in a sealed tube at 80 °C for 5 hours. After completion of the reaction, the solvent was removed by evaporation and the resulting crude product was used directly in the next step of the reaction without further purification (Yield: 3.56 g, Yield: 100%). The product [MH]+ was analyzed by liquid chromatography-mass spectrometry (LCMS, Method B) with m/z of 145.1 and retention time (tR) of 0.57 min.
141-30-0
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17284-97-8
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Yield:17284-97-8 100%
Reaction Conditions:
with hydrazine hydrate at 80; for 5 h;Sealed tube;
Steps:
L
Intermediate L6-((6-Chloro-[1 ,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline Acetic acid, 500C 3-Chloro-6-hydrazinylpyridazine (i) A mixture of 3,6-dichloropyridazine (3 g, 20.14 mmol) and hydrazine monohydride(1 g, 20.14 mmol) was heated in a sealed tube to 80 0C for 5 hours. Solvent was evaporated and the crude was used in the next step without purification (3.56 g, 100%). LCMS (method B): [MH]+ = 145.1 , tR = 0.57 min.
References:
WO2011/18454,2011,A1 Location in patent:Page/Page column 62-63
3916-78-7
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17284-97-8
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123-33-1
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17284-97-8
199 suppliers
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