3-CHLORO-N-(2,6-DICHLOROPHENYL)PROPANAMIDE synthesis

Yield:35714-74-0 55%

Reaction Conditions:

Stage #1: 2-chloropropionyl chloride;2,6-Dichloroanilinewith acetic acidHeating;
Stage #2: with sodium acetate in water;

Steps:

General procedure for synthesis of N,N-disubstituted aromatic β-chloropropion-amides 5g-h

General procedure: In a dry flask, a mixture of disubstituted amines (0.025 mol), glacial acetic acid (15 mL) and β-chloropropionylchloride (2.4 mL, 0.025 mol) was slightly warmed on hot plate for 1-2 min and to it was added sodium acetate (2.46 g, 0.030 mol) in 30 mL of water. The reaction mixture was cooled in ice bath. The product was filtered and dried and recrystallized from 50% ethanol. The physical data of the compounds are given in Table II.

References:

Vijayaraghavan;Shirodkar [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2015,vol. 54B,# 9,p. 1149 - 1153]