3-chloro-N-(2-chlorophenyl)benzamide synthesis
2synthesis methods
- Product Name:3-chloro-N-(2-chlorophenyl)benzamide
- CAS Number:83426-46-4
- Molecular formula:C13H9Cl2NO
- Molecular Weight:266.12
Yield:83426-46-4 90.2%
Reaction Conditions:
with pyridine for 2 h;Reflux;
Steps:
General procedure: A mixture of 0.53 ml (5 mmol) 2-cloroaniline, 0,58 mlbenzoyl chloride (5 mmol) and 5 ml of pyridine in a 50 mlround bottomed flask was refluxed for 2 hrs. After cooled toroom temperature, the reaction mixture was poured into 200ml of cold water and 5 ml of HCl 10% solution. The precipitateswere filtered, washed with water and dried at 60-70°C to give a crude product. Recrystallization from n-hexane/acetone furnished 1.01g of 2a.
References:
Nam, Nguyen Hai;Dung, Phan Thi Phuong;Thuong, Phuong Thien [Medicinal Chemistry,2011,vol. 7,# 2,p. 127 - 134]
