3-(CHLOROMETHYL)-5-(3,4-DICHLOROPHENYL)ISOXAZOLE synthesis
- Product Name:3-(CHLOROMETHYL)-5-(3,4-DICHLOROPHENYL)ISOXAZOLE
- CAS Number:338776-97-9
- Molecular formula:C10H6Cl3NO
- Molecular Weight:262.52
6287-38-3
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Yield:-
Steps:
Multi-step reaction with 6 steps
1: tetrahydrofuran / 3.17 h / 0 - 20 °C / Inert atmosphere
2: silica gel; manganese(IV) oxide / acetonitrile / 8 h / 70 °C / Molecular sieve
3: sodium hydride / toluene / 2 h / 90 °C
4: hydroxylamine hydrochloride / ethanol / 2 h / Reflux
5: sodium tetrahydroborate / ethanol; water / 20 °C
6: 1,2,3-Benzotriazole; thionyl chloride / dichloromethane / 20 °C
References:
Bi, Fangchao;Song, Di;Zhang, Nan;Liu, Zhiyang;Gu, Xinjie;Hu, Chaoyu;Cai, Xiaokang;Venter, Henrietta;Ma, Shutao [European Journal of Medicinal Chemistry,2018,vol. 159,p. 90 - 103]
2642-63-9
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1475-11-2
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$26.00/1g
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