3-(Chloromethyl)furan synthesis
- Product Name:3-(Chloromethyl)furan
- CAS Number:14497-29-1
- Molecular formula:C5H5ClO
- Molecular Weight:116.55
4412-91-3
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Yield:14497-29-1 84%
Reaction Conditions:
with thionyl chloride in dichloromethane at 0 - 20; for 1 h;
Steps:
1.2 Step 2: Preparation of 3-(chloromethyl furan (3)
To a stirred solution furan-3-ylmethanol (2, 0.5 g, 5.10 mmol) in DCM (5 mL), was added SOCl2(0.7 mL, 10.2 mmol) drop wise at 0 °C and the reaction mixture was stirred at rt for 1 h (Reaction condition b). The reaction mixture was evaporated under vacuum and dried to afford the product as brown oil (3) (0.5 g, 84%, Yield).XHNMR (400 MHz, DMSO-d6) δ (ppm): 7.75-7.65 (m, 2H), 6.53 (s, 1H), 4.68 (s, 2H).
References:
JUBILANT BIOSYS LIMITED;HALLUR, Gurulingappa;DURAISWAMY, Athisayamani Jeyaraj;PURRA, Buchi Reddy;RAO, N.V.S.K.;RAJAGOPAL, Sridharan;KRISTAM, Rajendra WO2019/77631, 2019, A1 Location in patent:Paragraph 000133; 000319
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