(3-chloropropyl)oxirane synthesis
- Product Name:(3-chloropropyl)oxirane
- CAS Number:19141-74-3
- Molecular formula:C5H9ClO
- Molecular Weight:120.58
89280-57-9
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19141-74-3
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Yield:19141-74-3 91.6%
Reaction Conditions:
with sodium hydroxide in dichloromethane at 15 - 25; for 1 h;Temperature;
Steps:
1.2; 2.2; 3.2
(2) (S) -1,5-dichloro-2-pentanol (157.2g, 1mol) obtained in step (1) Stir and mix with 600mL of dichloromethane, cool at 15 ° C, and add sodium hydroxide (44g, 1.1mol) in portions,The control temperature is not higher than 25 . After the addition, the reaction was stirred for 1 hour at 25 ° C.It was filtered and the filtrate was washed with 300 ml of purified water. Dry over anhydrous sodium sulfate and filter,The filtrate was concentrated to remove the solvent, and distilled under high vacuum to obtain 110.38 g of (S) -5-chloro-1,2-epoxypentane as a colorless liquid with a purity of 99.32% and a yield of 91.6%.
References:
CN110759853,2020,A Location in patent:Paragraph 0060; 0065; 0069; 0072; 0075; 0078
928-50-7
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$74.00/1g
19141-74-3
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821-09-0
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$21.21/1gm:
19141-74-3
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