3-CHLOROTHIOANISOLE synthesis

5synthesis methods

Product Name:3-CHLOROTHIOANISOLE
CAS Number:25697-57-8
Molecular formula:C7H7ClS
Molecular Weight:158.65

64215-09-4
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25697-57-8
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Yield:25697-57-8 81%

Reaction Conditions:

with tetraphosphorus decasulfide in toluene; for 3 h;Reflux;

Steps:

General experimental procedure:

General procedure: General experimental procedure: In a three-neck roundbottom flask, to a solution of thiocyanate (10 mmol) in toluene(25 mL), P2S5 (2.22 g, 10 mmol) was added and the resultingsuspension was refluxed till complete consumption of thestarting material (TLC). After the reaction was complete, thereaction mixture was quenched by careful addition of water(10 mL), extracted with ethyl acetate (3 × 10 mL), the organicphase was dried over sodium sulfate and evaporated underreduced pressure to get the crude product which was purified byflash chromatography (hexane-ethyl acetate) to get the purethiol.

References:

Maurya, Chandra Kant;Mazumder, Avik;Gupta, Pradeep Kumar [Beilstein Journal of Organic Chemistry,2017,vol. 13,p. 1184 - 1188] Location in patent:supporting information

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