3-Ethoxy-4-nitropyridine N-oxide synthesis
- Product Name:3-Ethoxy-4-nitropyridine N-oxide
- CAS Number:19349-73-6
- Molecular formula:C7H8N2O4
- Molecular Weight:184.15
Yield:19349-73-6 76%
Reaction Conditions:
in ethanol at 20; for 0.5 h;
Steps:
Under ice-cooling, 3-fluoro-4-nitropyridine 1-oxide (12 g, 76 mmol) and the mixed suspension of ethanol (300 mL), 20% sodium ethoxide ethanol solution (29g, 86mmol) was added to the . The temperature was raised to room temperature, and reacted under the same temperature for 30 minutes. The ethanol was evaporated under reduced pressure, and the residue water (200 mL) was added to, and the mixture was stirred for 15 minutes at room temperature. The solid was collected by filtration, washed with water and dried under reduced pressure to give 3-ethoxy-4-nitropyridine 1-oxide (11 g, 76% yield).
References:
JP2016/20335,2016,A Location in patent:Paragraph 0108
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