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ChemicalBook CAS DataBase List 3-ETHYL-1H-INDOLE-2-CARBOXYLIC ACID
92287-88-2

3-ETHYL-1H-INDOLE-2-CARBOXYLIC ACID synthesis

3synthesis methods
-

Yield:92287-88-2 96%

Reaction Conditions:

Stage #1: ethyl 3-ethyl-1H-indole-2-carboxylatewith sodium hydroxide in ethanol at 60;
Stage #2: with hydrogenchloride in ethanol; pH=2;

References:

Piscitelli, Francesco;Ligresti, Alessia;La Regina, Giuseppe;Coluccia, Antonio;Morera, Ludovica;Allarà, Marco;Novellino, Ettore;Di Marzo, Vincenzo;Silvestri, Romano [Journal of Medicinal Chemistry,2012,vol. 55,# 11,p. 5627 - 5631] Location in patent:supporting information; experimental part

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