3-ETHYL-3-METHYL-2-PENTANONE synthesis
- Product Name:3-ETHYL-3-METHYL-2-PENTANONE
- CAS Number:19780-65-5
- Molecular formula:C8H16O
- Molecular Weight:128.21
19889-37-3
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Yield:19780-65-5 92%
Reaction Conditions:
in tetrahydrofuran at 0 - 20;Inert atmosphere;
Steps:
1.3 Step 3: Synthesis of 3-ethyl-3-methyl-pentan-2-one
After dissolving 2-ethyl-2-methylbutyric acid (13.0g, 100mmol) in 200mL tetrahydrofuran,N2 was bubbled into the resulting solution for 3 minutes, and then it was cooled to 0°C,Then add 230mL 1.3M methyl lithium ether solution dropwise to it under N2 protection and 0,After the dropwise addition was completed, the reaction mixture was kept at 0° C. to continue the reaction for 2 hours, and then was raised to room temperature to react overnight.After TLC showed that the reaction was complete, 1M hydrochloric acid was slowly added to quench the reaction.Then separate the liquids, collect the organic phase, extract the aqueous phase twice with dichloromethane, combine the organic phases,The target product 3-ethyl-3-methyl-pentan-2-one (11.8 g, yield 92%) is obtained by drying and rotating.
References:
CN111909212,2020,A Location in patent:Paragraph 0159; 0166-0168
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